Launched in 2003 by the Bill & Melinda Gates Foundation as Grand Challenges in Global Health, this initiative initially focused on 14 major scientific challenges that, if solved, could lead to key advances in preventing, treating, and curing the diseases and health conditions contributing most to global health inequity. It was relaunched in 2014 as Grand Challenges, its new name reflecting its expanded scope encompassing challenges in global development. Explore awarded grants, watch grantee videos, read a 10-year retrospective of 14 of the original 44 projects, and watch videos from the 2014 (10th anniversary) Grand Challenges annual meeting in Seattle.