Floriano Silva of Fiocruz in Brazil will develop a drug screening assay using automated microscopy to test new drug candidates for toxicity towards adult helminth parasites, which cause a range of diseases. Current screening approaches cannot easily identify drugs that specifically target adult parasites, which is the most disease-relevant life cycle stage. He will develop and validate imaging and computational methods to automatically monitor physical characteristics of the parasites, and perform proof-of-principle drug screens using an FDA approved and an annotated compound library.