Product/Service Development

Katherine Klapperich of Boston University in the U.S. will develop a simple device that prepares and stores nucleic acid molecules from the blood for diagnostic testing without the need for a cold chain. Current costs for tests such as those to detect HIV are high, due largely to the need to keep the samples cold during transport to district laboratories. Removing the cold chain would also enable samples to be taken at more widespread locations and transported in batches to further reduce transport costs.

Sidney Sampson of Sydsam Integrated Services Limited in Nigeria will produce a low-cost wristband that can be worn by infants from birth until nine months that uses a flashing light to remind mothers when one of the five standard childhood vaccinations is due. Timely childhood vaccinations are critical for preventing deadly diseases, but many low-resource settings such as northwestern Nigeria have low immunization coverage rates and high dropout rates. They will design a waterproof silicon wristband in different colors and test it for user friendliness and safety.

Cheikh Tidiane Diagne of the Institut Pasteur de Dakar in Senegal will enable real-time remote sensing and monitoring of specimens during transport to laboratories in low-resource settings to facilitate diagnosis and assist researchers and health workers. Containing outbreaks during epidemics requires the early detection and rapid identification of pathogens, which means quickly and carefully collecting and transporting samples to laboratories. They will develop smart biosample preservation and transportation tools that can be monitored in real time with a remote digital interface.

Pratyusha Pareddy and Manoj Sanker of the Centre for Healthcare Entrepreneurship in collaboration with NemoCare Wellness in India will develop a small, battery-operated wearable device for newborns that continuously monitors vital signs in premature babies to alert health workers when a life-threating situation might occur, and provides vibration to stimulate breathing. Premature babies are susceptible to a variety of potentially fatal conditions such as apnea (suspension of breathing) and hypothermia.

Lee Schroeder of the University of Michigan in the U.S. will develop a smartphone application that can be used by health centers in Ghana to request independent drivers to transport patient samples quickly and at low cost to laboratories for diagnostic testing. Current courier services in resource-poor settings, when available, can be unreliable or expensive. A 'sharing economy' approach to delivery, by hiring independent drivers online, could improve services and reduce costs.

Joanna Bichsel of Kasha in Rwanda will adapt their mobile ecommerce platform to enable women in Kenya to confidentially order health products such as contraceptives and sanitary pads by mobile phone. There are many social barriers preventing women in developing countries from accessing products at health clinics. Their platform, Kasha, requires only a mobile phone to order and pay for products that are then delivered to local pick-up points. They have successfully implemented Kasha in Rwanda and will now perform a pilot study in several counties in Kenya.

We will manipulate the evolutionary trajectories to reverse the course of drug-resistant evolution of the parasites making them drug sensitive again. This revolutionary way of fighting drug resistance will pave way to malaria eradication by drugs.

This project will build and test a prototype application that streamlines and automates patient, provider and payer transactions across the maternal/newborn EOC. The goal is to pilot the application in Liberia, where the government must overcome operational challenges to engage private providers in the Liberia Health Equity Fund.

This project seeks to substantially expand access to oxytocin through the development of an affordable, simple to administer inhaled oxytocin delivery system. Using innovative technology, inhaled oxytocin is formulated as a fine powder that can withstand the climatic conditions common in tropical regions without the need for refrigeration. The product therefore removes the requirement for cold chain supply and storage, potentially allows task-shifting to lower tier healthcare and community workers and has the potential to save 146,000 lives over 8 years.

cStock is an approach to improving the supply of life-saving commodities to community health workers (CHWs) through technology - a mobile health logistics management information and resupply system (cStock) - while improving service delivery and demand generation through change management and system strengthening interventions - quality improvement teams. The approach is designed to make data visible, create a culture of data use, and drive accountability for performance.