Product/Service Development

Frans Walther of the Los Angeles Biomedical Research Institute in the U.S. will adapt a low-cost synthetic lung surfactant for aerosol delivery as a non-invasive and simple method to support breathing in premature infants. Surfactant is composed of lipids and proteins, and keeps the lungs open during expiration. It is normally administered to premature infants with breathing difficulties by tracheal intubation, which can be problematic in low-resource settings and cause side effects.

Xin Wang and colleagues from Brigham and Women's Hospital and Boston Medical Center in the U.S., along with collaborators from Weifang Medical University in China and Christian Medical College in India, will identify new treatments and associated diagnostic biomarkers for hypoxic-ischemic brain injury in newborns, which is a significant cause of morbidity and mortality. In Phase I they discovered that agonists of the melatonin receptor, alone or in combination with hypothermia, could prevent newborn hypoxic-ischemic brain injury in a mouse model.

Kiersten Israel-Ballard of PATH in the U.S., in partnership with University of Washington and Human Milk Banking (HMB) Association of South Africa, will work to develop and test a low-cost, cell-phone-based networked sensing system to provide safety monitoring of low-technology flash- heating pasteurization of breast milk designated for donation. The goal is to scale-up human milk banking for vulnerable infants in resource-limited settings.

Robert Borden of North Carolina State University in the U.S. will develop an inexpensive method to efficiently and hygienically remove human waste from cesspits. Borden will modify readily available gasoline powered augers and PVC pipes to operate as a progressive cavity pump for filling drums or other easily transported containers. In Phase I, Borden produced and tested an inexpensive machine that could effectively remove medium- to high-viscosity waste from a range of pits with different accessibilities in South Africa.

Nithya Ramanathan from Nexleaf Analytics in the U.S. will develop a low-cost mobile phone-based device to remotely monitor the temperature of refrigerated units that store and transport temperature-sensitive vaccines and drugs. In Phase I, they produced and tested a simple prototype temperature-sensing device and associated software that enables the wireless uploading of accurate temperature data for real-time monitoring, along with the ability to send SMS alerts upon reaching critical temperatures.

Olufunke Cofie of the International Water Management Institute in Ghana will develop and test fortified fertilizer pellets from treated human excreta for market sale. Production at large scale could enhance agricultural productivity in sub-Saharan Africa, while also contributing to reduction in environmental health risk from untreated human waste. In Phase I Cofie tested several materials that are inexpensive and locally available as binding agents for producing robust fecal sludge pellets suitable for packaging and transportation.

Nancy Muller from PATH in the U.S. will develop approaches to prevent freezing and thereby destruction of vaccines during cold chain transport. Maintaining vaccines below 8°C while preventing freezing is particularly challenging during their transport in developing countries. In Phase I they designed low-cost liners containing engineered phase change materials that fit existing vaccine carriers and provide a thermal buffer between the vaccines and standard ice-packs.

Chakib Tadj of École de Technologie Supérieure in Canada will design a non-invasive diagnostic tool using computer acoustical analysis of newborn cries to detect serious medical conditions such as heart defects and infections. Cry production in newborns can be influenced by neurological and physiological states. In this project's Phase I, Tadj and his team analyzed cries from 120 healthy and sick newborns to identify acoustic features that can be used for diagnostic purposes.

Abi Santhosh Aprem of HLL Lifecare Ltd. in India will attempt to eliminate the side effects associated with copper T intrauterine devices by coating the copper with biodegradable polymers. The polymers could prevent bulk shedding of copper ions that cause bleeding, cramping and pain, leading to increased acceptance of this highly effective contraceptive device.

Lawino Kagumba of ZanaAfrica in Kenya will develop and test sanitary pads that use a locally available agricultural by-product as an alternative low-cost absorbent material. This would enable low-income women and girls to have access to affordable feminine hygiene products, improving their productivity and menstrual health.