Alison Hill and Daniel Scholes Rosenbloom of Harvard University in the U.S., working with Seyed Alireza Rabi and Greg Laird of Johns Hopkins University in the U.S., propose to engineer a gene therapy that delivers a viral transcription factor to reactivate CD4 cells that are latently infected with HIV along with a suicide gene that is triggered by HIV protein production to effectively kill the infected cells. This therapy could allow complete clearance of HIV from the body and a permanent cure for HIV infection.