Dominant Lethal Probes to Investigate Latency in TB

Babak Javid of the Harvard School of Public Health in the U.S. will explore the hypothesis that latent bacteria are metabolically active during latency. The physiology of the tuberculosis bacteria during latency is not well understood. The team will use novel genetic probes to determine whether transcription and translation occur in the population of cells that are responsible for re-activation of TB from models of latency.