Biomarkers for Bacteremia, Antimicrobial Resistance and Hospital Acquired Infections By NMR and Mass Spectrometry Among Febrile Neutropenic Patients

The project proposes use of metabolomics including High throughput Nuclear Magnetic Resonance (NMR) spectroscopy and Liquid-chromatography mass spectrometry (LC-MS) as a powerful tool for the discovery of biomarkers for differentiating bacteremic cases and non-bacteremic cases among febrile neutropenic Cancer patients to decrease antibiotic consumption, differentiating antimicrobial resistance extended spectrum beta-lactamase (ESBL) present or not based on metabolites and differentiating community acquired blood stream infections and hospital acquired blood stream infections including Central line associated blood stream infections (CLABSI) based on metabolomics. This will greatly reduce the antibiotic consumption, selection of drug-resistant strains, antibiotic associated complications, hospital acquired infections